Esophageal cancer is a commonly occurring cancer in both men and women. While its origins continue to mystify experts, some believe that it may partially come from constant irritation of the esophagus. Drinking alcohol, gastroesophageal reflux disease (GERD), obesity, and smoking are some of the likeliest sources of esophageal irritation. (: What do turmeric, apples and grapes have in common? Scientists have found they all help treat prostate cancer.)
Mauritian medicinal herbs halt growth of esophageal cancerThe research team analyzed extracts taken from Acalypha integrifolia, Eugenia tinifolia, and Labourdonnaisia glauca – medicinal herbs found only in Mauritius. They found the extracts contained compounds that might inhibit the progression of cancer tumors. Results showed that the plant-based substances activated 5′ AMP-activated kinase (AMPK) signaling pathway, which is responsible for regulating metabolic processes. Earlier studies have found that APMK activators interfere with tumor growth by cell cycle arrest and apoptosis. Researchers often search for ways to activate AMPK signaling pathways to treat cancer and other chronic diseases.
“About one-third of the local plants are used in traditional medicine, but there is still a lack of scientific evidence of their therapeutic potential,” explained Alexander Kagansky, a co-author of the study. “To date, only 15 percent of the island’s plant species have been examined for their medicinal properties, which is still better than in many countries.”
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Natural sources of anti-cancer compoundsKagansky and his colleagues tested the extracts on human cancer cell lines. Of the five biologically active plant compounds, three successfully stopped esophageal cancer cells from growing and expanding. They showed promise as natural therapies for cancer.
Around the world, people rely on similar plants to treat various cancers. Those medicinal herbs have seen much use in folk medicine for centuries. Many researchers posit that modern biomedicine must look into these natural sources for anti-cancer compounds. They believe that bacteria, fungi, and plants might have ways to treat cancer without the severe side effects of modern chemotherapy.
Based on their findings, the future of medicine might depend on maintaining biodiversity. Humans must find a way to preserve beneficial plant and animal species.
“Our research should serve the benefit of humanity and show by evidence that, on the mechanistic level, people depend on natural chemistries, which will reward us by reducing deaths and suffering of ourselves, our parents, and children,” Kagansky said.
The study was published in the scientific journal Acta Naturae.
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