Eating too much fat and sugar as a child can alter your microbiome for life, even if you later learn to eat healthier, a new study in mice suggests.The study by UC Riverside researchers is one of the first to show a significant decrease in the total number and diversity of gut bacteria in mature mice fed an unhealthy diet as juveniles. "We studied mice, but the effect we observed is equivalent to kids having a Western diet, high in fat and sugar and their gut microbiome still being affected up to six years after puberty," explained UCR evolutionary physiologist Theodore Garland.
A paper describing the study has recently been published in the Journal of Experimental Biology.
Exercise regularly. If you can exercise don’t just a few times a week, but every day. Movement is key to a healthy life. Exercising daily can improve your health in many ways. It can help increase your life span, lower your risk of diseases, help you develop higher bone density, and lose weight.
The microbiome refers to all the bacteria as well as fungi, parasites, and viruses that live on and inside a human or animal. Most of these microorganisms are found in the intestines, and most of them are helpful, stimulating the immune system, breaking down food and helping synthesize key vitamins.
In a healthy body, there is a balance of pathogenic and beneficial organisms. However, if the balance is disturbed, either through the use of antibiotics, illness, or unhealthy diet, the body could become susceptible to disease.
In this study, Garland's team looked for impacts on the microbiome after dividing their mice into four groups: half fed the standard, 'healthy' diet, half fed the less healthy 'Western' diet, half with access to a running wheel for exercise, and half without.
Know your limits. The healthiest version of ourselves lies somewhere between giving ourselves grace while still having challenging goals. A good place to start is by being honest with yourself about what works for you and what doesn’t.
After three weeks spent on these diets, all mice were returned to a standard diet and no exercise, which is normally how mice are kept in a laboratory. At the 14-week mark, the team examined the diversity and abundance of bacteria in the animals.
They found that the quantity of bacteria such as Muribaculum intestinale was significantly reduced in the Western diet group. This type of bacteria is involved in carbohydrate metabolism. Analysis also showed that the gut bacteria are sensitive to the amount of exercise the mice got. Muribaculum bacteria increased in mice fed a standard diet who had access to a running wheel and decreased in mice on a high-fat diet whether they had exercise or not.
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Researchers believe this species of bacteria, and the family of bacteria that it belongs to, might influence the amount of energy available to its host. Research continues into other functions that this type of bacteria may have.
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One other effect of note was the increase in a highly similar bacteria species that were enriched after five weeks of treadmill training in a study by other researchers, suggesting that exercise alone may increase its presence.Overall, the UCR researchers found that early-life Western diet had more long-lasting effects on the microbiome than did early-life exercise.
Garland's team would like to repeat this experiment and take samples at additional points in time, to better understand when the changes in mouse microbiomes first appear, and whether they extend into even later phases of life.
One simple thing you can do is, especially for close distances, choose walking over riding, driving or taking transportation. You can climb the stairs instead of taking the elevator. You can pick exercises that are easy to do at home or outside that you enjoy. When you enjoy the physically activities you choose for yourself, most likely you’ll enjoy them and naturally want to do them. Exercise is about being healthy and having fun at the same time. Also, mixing up your exercises will keep them interesting.
Regardless of when the effects first appear, however, the researchers say it's significant that they were observed so long after changing the diet, and then changing it back.
The takeaway, Garland said, is essentially, "You are not only what you eat, but what you ate as a child!"