- Rheumatoid arthritis is a systemic and inflammatory autoimmune disease whose treatment remains a challenge due to adverse effects caused by conventional medicines.
- For their experiment, the researchers induced rheumatoid arthritis by inoculating 0.1 mL CFA in rats.
- They then fed the animals daily for 10 days with distilled water (10 mL/kg), sodium diclofenac (5 mg/kg) and the aqueous extract of T. globiferus at 50, 100 and 200 mg/kg.
- Meanwhile, they gave healthy rats (control) only distilled water (10 mL/kg).
- The researchers then measured the volume of edema of the hind paw using a plethysmometer and collected samples for hematological, biochemical and histological analyses.
- The aqueous extract of T. globiferus significantly alleviated the physiological impairment brought about by rheumatoid arthritis.
- It did so by protecting the animals from anemia and leukocytosis and reducing the volume of hind paw edema, transaminase activity, alkaline phosphatase levels and hypercreatinemia.
- The aqueous extract of T. globiferusalso improved the antioxidant status of the animals, as well as the architectural organization at the joint level.
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Based on these findings, the researchers concluded that T. globiferusis a natural medicine for rheumatoid arthritis because it can reverse physiological dysfunctions caused by the disease.
Journal Reference:Raceline GK, Aubin NKB, Jaures TNM, Ducos YF, Florence NT, Desire DDP, Theophile D, Beng VP. ANTI-INFLAMMATORY POTENTIAL OF TAPINANTHUS GLOBIFERUS (LORANTHACEAE) LEAVES AS AN ALTERNATIVE TREATMENT AGAINST ARTHRITIS. The Journal of Phytopharmacology. 2019;8(3):96-103