"We studied mice, but the effect we observed is equivalent to kids having a Western diet, high in fat and sugar and their gut microbiome still being affected up to six years after puberty," explained UCR evolutionary physiologist Theodore Garland.
To investigate the link between the gut microbiota and muscle health, the researchers transferred fecal samples from the adults into germ-free, gender-matched mice.In a study published in Science Translational Medicine , researchers found that mice with gut microbes had stronger skeletal muscles compared to germ-free mice.
(Yu et al., 2020 | Nature Immunology) The folds of the inner mitochondrial membrane (i.e., cristae) are increased in T lymphocytes present in normal spleens compared to tumors, indicating that the tumor microenvironment caused T cell mitochondrial dysfunction.
(Xie et al., 2020 | Journal of Affective Disorders) NMN supplementation improves body weight to normal in mice with stress hormone-induced depressive symptoms.“Our findings indicate that NMN supplementation can effectively enhance SIRT3 activity to improve mitochondrial energy metabolism in the hippocampus and liver, thereby mitigating [corticosterone]-induced depression-like behavior in mice,” stated the researchers in their study.
Published in the Journal of Functional Foods , the study reported that the extract helps regulate blood sugar and cholesterol in older mice fed a high-fat diet.The fourth and fifth groups consisted of older mice fed a standard diet and the jaboticaba peel extract.
As our body ages, a core clock repressor, PER2, increases and dampens the activity of our circadian rhythms through repressing BMAL1.The level of NAD+ regulates the degradation of PER2, which in turn promotes the activity of BMAL1, keeping the internal clock ticking at a healthy pace.
Transcriptome and metabolome analyses revealed that in depressed mice, NMN reduced the mRNA expression of genes involved in fatty acid synthesis, stimulation of β-oxidation and glycolysis, and increased production of acetyl-coenzyme A for the tricarboxylic acid cycle.
A recent study, which took place at the Harvard T.H. Chan School of Public Health in Boston, Massachusetts, found that consumption of propionate, a preservative frequently added to foods, may be associated with an increased risk of obesity and diabetes.
Natural Health News — A food ingredient widely used in baked goods, animal feeds and artificial flavourings, appears to increase levels of several hormones that are associated with risk of obesity and diabetes, according to new research.
The researchers found that the mice fed the high fat diet gave birth to offspring with an increased risk of getting NAFLD. The PQQ supplementation in those fed the high fat diet did not influence their weight gain, but it reduced the fat and inflammation in their livers even prior to birth.
Another thing that the researchers found out was that all of the mice that were fed the low-fiber WSD diet showed a lower rate of gut mucous growth compared with the ones who were fed the standard control diet.
Turns out, a particular gut bacteria seems to use fiber to reduce atherosclerosis and inflammation in mice. Mice with Roseburia who ate a high-fiber diet suffered less atherosclerosis and inflammation. The findings: A particular fatty acid, butyrate, is the mechanism through which a high-fiber diet protects the heart in mice.
Now, research out of Scotland suggests a type of sugar called mannose, found in cranberries and other fruits, may be useful in the treatment of certain cancers.
Tetrahydrocannabinol (THC), the compound responsible for marijuana’s psychoactive effects, may offer hope for treating Alzheimer’s disease, at least according to a study on mice.1 Rodents with a disease similar to Alzheimer’s were given a synthetic form of THC, which resulted in fewer lost brain cells, 20 percent less sticky plaques in the brain (which are linked to Alzheimer’s) as well as a boost in memory.
The researchers were surprised to find the effects of obesity on gut bacteria, inflammation and OA were prevented when the high-fat diet was supplemented with oligofructose.
The chemical in cannabis that makes people feel ‘high’ appears to improve learning and memory in older mice, a new study has found – with similar tests on humans planned for later this year.