As our body ages, a core clock repressor, PER2, increases and dampens the activity of our circadian rhythms through repressing BMAL1.The level of NAD+ regulates the degradation of PER2, which in turn promotes the activity of BMAL1, keeping the internal clock ticking at a healthy pace.
Transcriptome and metabolome analyses revealed that in depressed mice, NMN reduced the mRNA expression of genes involved in fatty acid synthesis, stimulation of β-oxidation and glycolysis, and increased production of acetyl-coenzyme A for the tricarboxylic acid cycle.
A recent study, which took place at the Harvard T.H. Chan School of Public Health in Boston, Massachusetts, found that consumption of propionate, a preservative frequently added to foods, may be associated with an increased risk of obesity and diabetes.
Natural Health News — A food ingredient widely used in baked goods, animal feeds and artificial flavourings, appears to increase levels of several hormones that are associated with risk of obesity and diabetes, according to new research.
The researchers found that the mice fed the high fat diet gave birth to offspring with an increased risk of getting NAFLD. The PQQ supplementation in those fed the high fat diet did not influence their weight gain, but it reduced the fat and inflammation in their livers even prior to birth.
Food Emulsifiers May Affect Brain and Behavior Previous research has shown that adding the food emulsifiers CMC and P80 to the diet leads to low-grade inflammation, obesity and metabolic abnormalities in mice, while disturbing gut microbiota .
Turns out, a particular gut bacteria seems to use fiber to reduce atherosclerosis and inflammation in mice. Mice with Roseburia who ate a high-fiber diet suffered less atherosclerosis and inflammation. The findings: A particular fatty acid, butyrate, is the mechanism through which a high-fiber diet protects the heart in mice.
Tetrahydrocannabinol (THC), the compound responsible for marijuana’s psychoactive effects, may offer hope for treating Alzheimer’s disease, at least according to a study on mice.1 Rodents with a disease similar to Alzheimer’s were given a synthetic form of THC, which resulted in fewer lost brain cells, 20 percent less sticky plaques in the brain (which are linked to Alzheimer’s) as well as a boost in memory.
The researchers were surprised to find the effects of obesity on gut bacteria, inflammation and OA were prevented when the high-fat diet was supplemented with oligofructose.